References

1. Brown Michael, Charles A. yowell, anna Hoard, Thomas A. Vander Jagt, Lucy A. Hunsaker, Lorraine M. Deck, Robert E. Royer, Robert C. Piper, John B. Dame, Michael T. Makler, and David L. Vander Jagt, “Comparative Structural Analysis and Kinetic Properties of Lactate Dehydrogenases from the Four Species of Human Malarial Parasites,” Biochemistry 2004: 6219-29.

2. Cameron, Angus, Jon Read, Rebecca Tranter, Victoria J. Winter, Richard B. Sessions, R. Leo Brady, Livia Vivas, Anna Easton, Howard Kendrick, Simon L. Croft, David Barros, Jose Luis Lavandera, Jose Julio Martin, Felix Risco, Silvestre Garcia-Ochoa, Fracisco Javier Gamo, Laura Sanz, Luisa Leon, Jose R. Ruiz, Raquel Gabarro, Araceli Mallo, and Federico Gomez de las Heras, “Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity,” The Journal of Biological Chemistry 23 July 2004: 31429-31439.

3. Chaikuad, Apirat, Victoria Fairweather, Rebecca Conners, Tim Joseph-Horne, Dilek Turgut-Balik, and R. Leo Brady,“Structure of Lactate Dehydrogenase from Plasmodium vivax: Complexes with NADH and APADH,” Biochemistry 20 July, 2005: 16221-16228.

4. Choi, Seoung-ryoung, Anupam Pradhan, Nicholas L. Hammond, Amar G. Chittiboyina, Babu L. Tekwani, and Mitchell A. Avery, “Design, Synthesis, and Biological Evaluation of Plasmodium falciparum Lactate Dehydrogenase Inhibitors,” J. Med. Chem 22 March, 2007: 3841-3850.

5. Conners, Rebecca, et al., “Mapping the Binding Site for Gossypol-like Inhibitors of Plasmodium falciparum Lactate Dehydrogenase,” Molecular & Biochemical Parasitology 2005: 137-148.

6. Holm L, Rosenström P (2010) Dali server: conservation mapping in 3D. Nucl. Acids Res. 38, W545-549.

7. Image from the RCSB PDB (www.pdb.org) of PDB ID 1T2C Cameron, Angus, Jon Read, Rebecca Tranter, Victoria J. Winter, Richard B. Sessions, R. Leo Brady, Livia Vivas, Anna Easton, Howard Kendrick, Simon L. Croft, David Barros, Jose Luis Lavandera, Jose Julio Martin, Felix Risco, Silvestre Garcia-Ochoa, Fracisco Javier Gamo, Laura Sanz, Luisa Leon, Jose R. Ruiz, Raquel Gabarro, Araceli Mallo, and Federico Gomez de las Heras, “Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity,” The Journal of Biological Chemistry 23 July 2004: 31429-31439.)

8. Kabsch W., Sander C. “Dictionary of Protein Secondary Structure: Pattern Recognition of Hydrogen-bonded and Geometrical Features.” Biopolymers, Dec. 1983, 3 Oct. 2010 <http://www.pdb.org/pdb/explore/remediatedSequence.do?structureId=1T2C&params.showDbRefRulerIfPossible=true&params.desiredSequenceRnsStr=DBREF> PMID: 6667333

9. Murzin A.G., Brenner S.E., Hubbard T., Chothia C. “SCOP: A Structural Classification of Proteins Database for the Investigation of Sequences and Structures.” ­J Mol Biol, April 1995, 3 Oct. 2010 <http://www.pdb.org/pdb/explore/remediatedSequence.do?structureId=1T2C&params.showDbRefRulerIfPossible=true&params.desiredSequenceRnsStr=DBREF> PMID: 7723011

10. Sessions Richard B., Victoria Dewar, Anthony R. Clarke, and J. John Holbrook. “A Model of Plasmodium falciparum Lactate Dehydrogenase and its Implications for the Design of Improved Antimalarials and the Enhanced Detection of Parasitaemia,” Protein Engineering 1997: 301-306.

11. Dunn, Cameron R., Mark J. Banfield, John J. Barker, Christopher W. Higham, Kathleen M. Moreton, Dilek Turgut-Balik, R. Leo Brady and J. John Holbrook. “The Structure of Lactate Dehdyrogenase from Plasmodium falciparum Reveals a New Target for Anti-Malarial Design,” Nature Structural Biology Nov. 1996: 912-915.

12. Wiwanitkit, Viroj, “Plasmodium and Host Lactate Dehydrogenase Molecular Function and Biological Pathways: Implication for Antimalarial Drug Discovery,” Chem Biol Drug Des 2007: 280-283.